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                      Findings In Yeast Sheds Light On Calorie Restriction

                      Published by Life Extension

                      The journal Nature published an article online on November 21, 2012 that provides new information on how calorie restriction extends life span.

                      Adam L. Hughes, PhD and Daniel Gottschling, PhD of Seattle’s Fred Hutchinson Cancer Research Center report the results of their latest research involving yeast cells. They found that a structure within the cells known as the vacuole (whose animal counterpart is the lysosome) becomes less acidic early in the yeast cell’s life span, resulting in a reduction in the ability of this organelle to store specific nutrients. These nutrients build up in the cell and overwhelm the mitochondria, which are the cell’s power plants. When the mitochondria become exhausted by consuming the surplus, they become dysfunctional. “Until now, the vacuole’s role in breaking down proteins was thought to be of primary importance,” explained Dr Hughes, who is a postdoctoral fellow in Dr Gottschling’s laboratory. “We were surprised to learn it was the storage function, not protein degradation, that appears to cause mitochondrial dysfunction in aging yeast cells.”

                      “Normally, mitochondria are beautiful, long tubes, but as cells get older, the mitochondria become fragmented and chunky,” noted Dr Gottschling, who is a member of the Fred Hutchinson Center’s Basic Sciences Division. “The changes in shape seen in aging yeast cells are also observed in certain human cells, such as neurons and pancreatic cells, and those changes have been associated with a number of age-related diseases in humans.”

                      “There has been a lot in the scientific literature and the general media lately about how what you eat affects the aging process, but it has been incredibly confusing,” Dr Gottschling remarked. “Now we have a new paradigm for understanding how genetics and environment interact to influence lifespan, aging and age-related diseases. That’s what I’m really excited about.”

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                      Life Extension
                      Life Extension
                      LIFE EXTENSION The Life Extension Health News team delivers accurate information about vitamins, nutrition and aging. Our stories rely on multiple, authoritative sources and experts. We keep our content accurate and trustworthy, by submitting it to a medical reviewer. Life Extensionists are people who believe in taking advantage of documented scientific therapies to help maintain optimal health and slow aging. The medical literature contains thousands of references on the use of antioxidant vitamins, weight loss supplements, and hormones that have been shown to improve the quality and quantity of life. Life Extensionists attempt to take advantage of this scientific information to enhance their changes of living longer in good health. This article is posted by permission of Life Extension.

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                      This website is for informational and entertainment purposes only and is not a substitute for medical advice, diagnosis or treatment. FoodTrients – A Recipe for Aging Beautifully Grace O, author and creator of FoodTrients® -- a philosophy, a cookbook and a resource -- has a new cookbook dedicated to age-defying and delicious recipes, The Age Beautifully Cookbook: Easy and Exotic Longevity Secrets from Around the World, which provides one hundred-plus recipes that promote health and well-being. The recipes are built on foundations of modern scientific research and ancient knowledge of medicinal herbs and natural ingredients from around the world. Since the publication of her first anti-aging book, The Age GRACEfully Cookbook, Grace O has identified eight categories of FoodTrients benefits (Anti-inflammatory, Antioxidant, Immune Booster, Disease Prevention, Beauty, Strength, Mind, and Weight Loss) that are essential to fighting aging, which show how specific foods, herbs, and spices in the recipes help keep skin looking younger, prevent the diseases of aging, and increase energy and vitality. Grace O combines more exotic ingredients that add age-fighting benefits to familiar recipe favorites.

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