Cranberry Benefits May Extend to the Gut, Heart and Brain

Cranberry juice on old wooden table

While decades of cranberry research has found that regular consumption of cranberry products promotes urinary tract health, leading scientists studying the bioactive components of fruits and other foods reported that cranberries possess whole body health benefits. In a July 2016 Advances in Nutrition supplement, Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015, a team of international researchers reviewed the complex, synergistic actions of compounds that are uniquely cranberry. Their discussion led them to conclude that this berry may be more than just a tart and tangy fruit.

“It has been established that cranberries rank high among the berry fruits that are rich in health-promoting polyphenols,” notes lead author, Jeffrey Blumberg, PhD, of the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Boston, MA. “But now, recent investigations have shown that the cranberry polyphenols may interact with other bioactive compounds in cranberries that could protect the gut microbiota, and provide antioxidant and anti-inflammatory functions that benefit the cardiovascular system, metabolism and immune function.”


Recognition of the important role gut microorganisms play in human health has gained attention of scientists, reaching all the way up to the White House with the National Microbiome Initiative. Emerging evidence has found that the gut microbiome may impact the health of the immune system and brain, as well as how the body balances energy and uses carbohydrates and fat. Preliminary investigations with cranberries, some of which were performed in animal models, have revealed that cranberry bioactives show promise in helping to strengthen the gut defense system and protect against infection.

The effect of cranberry products on cardiovascular health and glucose management was also explained in the review. Authors of the paper described promising links between cranberry products and blood pressure, blood flow and blood lipids. One study identified a potential benefit for glucose management with low-calorie cranberry juice and unsweetened dried cranberries for people living with type 2 diabetes. Benefits for heart health and diabetes management have been attributed to the antioxidant and anti-inflammatory effects of the polyphenols in cranberries.

Given the wide range of ways to consume cranberries – juice, fresh, sauce, dried, or as an extract in beverages or supplements – additional human studies will help determine all the ways that cranberries may influence health. The scientific community and the cranberry industry agree – the impressive potential that cranberry bioactives may have on public health is worthy of further exploration.

“The bioactives in cranberry juice, dried cranberries and a variety of other cranberry sources have been shown to promote an array of beneficial health effects,” explains Dr. Blumberg. “Given the complex nature and diversity of compounds found in berry fruits and how they interact with each other, I believe we have only scratched the surface when it comes to identifying the potential power of the cranberry.”

To read the proceedings in their entirety, the Advances in Nutrition supplement can be accessed here: Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015.

The Cranberry Health Research Conference was sponsored by the Cranberry Institute, with grant support provided by the Cranberry Marketing Committee (CMC), an instrumentality of the United States Department of Agriculture, Agriculture Marketing Service (USDA/AMS), that administers the Cranberry Marketing Order, 7 Code of Federal Regulations 929, as authorized under the Agricultural Marketing Agreement Act of 1937, as amended, and theAmerican Cranberry Growers Association.

For more information about the Cranberry Institute, along with the health benefits of cranberries and current scientific research, visit:

About the Cranberry Health Research Conference (CHRC)

Chaired by Dr. Jeffrey Blumberg of Tufts University’s Jean Mayer USDA Human Nutrition Research Center on Aging and Friedman School of Nutrition Science and Policy, the invitation-only CHRC preceded the Berry Health Benefits Symposium held October 13-15, 2015. The program brought together a select group of researchers and industry professionals to present current research and foster rigorous dialogue, integrate knowledge of cranberry health benefits across disciplines and identify critical gaps to be addressed by future research.

About the Cranberry Institute

The Cranberry Institute is a not-for-profit organization founded in 1951 to further the success of cranberry growers and the industry in the Americas through health, agricultural and environmental stewardship research as well as cranberry promotion and education. The Cranberry Institute is funded voluntarily by Supporting Members that handle, process, and sell cranberries. Supporting Members are represented in national and international regulatory matters and research efforts are done on their behalf.

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