How Aspirin Works Against Cancer

closeup of white pills

Aspirin’s association with a lower risk of numerous types of cancer has been attributed to its anti-inflammatory effect; however, research reported in the February 2017 issue of Cancer Prevention Research suggests another potential mechanism.

In experiments utilizing colon cancer cells and a mouse model of colon cancer, Houston researchers observed that aspirin prevented the cancer-promoting interaction between cancer cells and platelets by inhibiting cyclooxygenase-1 (COX-1)-mediated platelet activation. Platelets are involved in the formation of new blood vessels which, although beneficial in most cases, enhances tumor growth.

While common aspirin was used in some of the experiments, other experiments utilized a complex of aspirin with phosphatidylcholine, a lipid that occurs in lecithin. The combination, which is being developed under the name of Aspirin-PC/PL220 by a pharmaceutical company, has fewer gastrointestinal risks than regular aspirin, and in the current research, it was shown to have stronger anticancer effects.

“These results suggest that aspirin’s chemopreventive effects may be due, in part, to the drug blocking the proneoplastic action of platelets and the potential use of Aspirin-PC/PL2200 as an effective and safer chemopreventive agent for colorectal cancer and possibly other cancers,” authors Lenard M. Lichtenberger and colleagues conclude.

The researchers plan to evaluate the aspirin/phosphatidylcholine complex’s effects among those at high risk for colorectal cancer. While they state that their results “support the use of low-dose aspirin for chemoprevention,” Dr Lichtenberger and colleagues note that the aspirin/phosphatidylcholine combination has “similar chemopreventive actions to low-dose aspirin and may be more effective.”

About Life Extension

Life Extensionists are people who believe in taking advantage of documented scientific therapies to help maintain optimal health and slow aging. The medical literature contains thousands of references on the use of antioxidant vitamins, weight loss supplements, and hormones that have been shown to improve the quality and quantity of life. Life Extensionists attempt to take advantage of this scientific information to enhance their chances of living longer in good health.
What Do FoodTrients Do?
Ai Anti- inflammatories

Reduce inflammatory process in cells, tissues, and blood vessels, helping to slow aging and reduce risk of long-term disease.

Ao Anti- oxidant

Prevents and repairs oxidative damage to cells caused by free radicals.

IB Immunity Boosters

Support the body’s resistance to infection and strengthen immune vigilance and response.

MB Mind

Improves mood, memory, and focus.

F Disease Prevention

Reduces risk factors for common degenerative and age-related diseases.