The August 2015 issue of the Journal of Nutritional Biochemistry published the finding of researchers at Kaohsiung Medical University in Taiwan of a lifespan-extending effect for an aqueous extract of garlic when given to Caenorhabditis elegans, a roundworm commonly used in gerontological experiments. “Advantages and beneficial effects of garlic (A. sativum) consumption have been widely investigated, eliciting great interests especially for medical researchers,” note Chun-Hao Huang and colleagues in their introduction. “Although some previous studies have shown that garlic extract or some of its components may have potential anti-aging effects, systematic approaches to show the lifespan-promoting effect of garlic extract at the molecular and biosignaling levels are still lacking.”
When C. elegans was supplemented with garlic extract, lifespan increased by 21% in comparison with worms treated with water. The effect was found to be dependent upon the expression of a transcription factor known as daf-16, which was determined to be activated by the garlic compounds mannose-binding lectin and the amino acid N-acetylcysteine (NAC).
In a previous experiment, the team discovered a lifespan-enhancing effect for acetic acid (vinegar) in C. elegans. Dr Huang and colleagues found that acetic acid combined with aqueous garlic extract activated daf-16 to a greater extent than either agent alone, which suggests the possibility of upregulation of this pathway by a combination of compounds.
“Our results establish aqueous garlic extract as a promising lifespan-promoting herbal remedy and highlight the utility of integrated metabolo-proteomics for revealing biologically active components in commonly consumed foods and natural products,” they conclude.
Reduce inflammatory process in cells, tissues, and blood vessels, helping to slow aging and reduce risk of long-term disease.
Prevents and repairs oxidative damage to cells caused by free radicals.
Support the body’s resistance to infection and strengthen immune vigilance and response.
Improves mood, memory, and focus.
Reduces risk factors for common degenerative and age-related diseases.