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                      Melatonin Promotes Calorie-Burning “Beige Fat”

                      Published by Life Extension

                      An article published online on September 6, 2013 in the Journal of Pineal Research describes the findings of researchers at the University of Granada in Spain of a benefit for melatonin, a hormone involved in sleep and circadian rhythms, in a rat model of metabolic syndrome and obesity.

                      Acting on the results of other research which uncovered an antiobesity effect for melatonin in Zücker diabetic fatty (ZDF) rats, Ahmad Argil of the University of Granada’s School of Medicine and his associates gave ZDF rats and their lean littermates drinking water supplemented with or without melatonin for six weeks, beginning at five weeks of age. They found that melatonin induced browning of white adipose tissue in both strains that received it. (Unlike white fat, “beige fat” burns calories rather than storing them.) Animals that received melatonin exhibited increased inguinal temperature and greater sensitivity to the thermogenic effect of cold exposure, which stimulates the burning of calories to maintain body temperature. Treated rats also demonstrated an increase in uncoupling protein 1, which is expressed by beige fat mitochondria.

                      Dr Agil hopes that his team will continue investigating melatonin “to be able to achieve their final objective: to confirm these findings in humans, by administering melatonin to help combat obesity and diabetes”.

                      “These results demonstrate that chronic oral melatonin drives white adipose tissue into a brown-fat-like function in ZDF rats,” Dr Agil and his coauthors conclude. “This may contribute to melatonin′s control of body weight and its metabolic benefits.”

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                      Life Extension
                      Life Extension
                      LIFE EXTENSION The Life Extension Health News team delivers accurate information about vitamins, nutrition and aging. Our stories rely on multiple, authoritative sources and experts. We keep our content accurate and trustworthy, by submitting it to a medical reviewer. Life Extensionists are people who believe in taking advantage of documented scientific therapies to help maintain optimal health and slow aging. The medical literature contains thousands of references on the use of antioxidant vitamins, weight loss supplements, and hormones that have been shown to improve the quality and quantity of life. Life Extensionists attempt to take advantage of this scientific information to enhance their changes of living longer in good health. This article is posted by permission of Life Extension. https://www.lifeextension.com/

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                      This website is for informational and entertainment purposes only and is not a substitute for medical advice, diagnosis or treatment. FoodTrients – A Recipe for Aging Beautifully Grace O, author and creator of FoodTrients® -- a philosophy, a cookbook and a resource -- has a new cookbook dedicated to age-defying and delicious recipes, The Age Beautifully Cookbook: Easy and Exotic Longevity Secrets from Around the World, which provides one hundred-plus recipes that promote health and well-being. The recipes are built on foundations of modern scientific research and ancient knowledge of medicinal herbs and natural ingredients from around the world. Since the publication of her first anti-aging book, The Age GRACEfully Cookbook, Grace O has identified eight categories of FoodTrients benefits (Anti-inflammatory, Antioxidant, Immune Booster, Disease Prevention, Beauty, Strength, Mind, and Weight Loss) that are essential to fighting aging, which show how specific foods, herbs, and spices in the recipes help keep skin looking younger, prevent the diseases of aging, and increase energy and vitality. Grace O combines more exotic ingredients that add age-fighting benefits to familiar recipe favorites.

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