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                      Immune Response Increases Heart Attack Deaths

                      Published by Life Extension

                      Heart abstract shape in the hand.

                      Dying heart cells cause an immune response that increases heart attack fatality, according to a study in mice led by UC San Diego and Harvard University researchers. Temporarily suppressing the immune response improved survival from about 60 percent to more than 95 percent, the study found.

                      If the results apply to people, it could result in new therapies to reduce the toll from heart disease, the country’s leading cause of death. But developing those therapies could take years.

                      The study was published Monday in Nature Medicine. UCSD’s David King, formerly of Harvard, was first author. Ralph Weissleder was senior author.

                      Researchers found that DNA released from the dying cells triggers an immune response normally activated by viral infections. It begins with a previously unknown set of cardiac macrophages, immune cells that engulf pathogens and cellular debris.

                      The macrophages interpret the DNA as indicating a viral infection, provoking production of signaling proteins called interferons. These are made in response to infections as well as cancer. This leads to an inflammatory response that further harms the heart.

                      In the mouse model, blocking this response either genetically or chemically increased survival.

                      There is precedent to think that this therapy could work in people, the study said.

                      “Therapeutically, cancer immunotherapy and vaccine adjuvants aim to boost innate immunity, the study stated. “Here we suggest that transient inhibition of the interferon-dependent innate immune response to ischemic cell death could reduce inflammation and limit the adverse ventricular remodeling that leads to clinical heart failure.”

                      “Humans tolerate the anti-interferon biologics that are in clinical development for rheumatologic indications, suggesting the feasibility of targeting the interferon response in MI (heart attacks)”.

                       

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                      Life Extension
                      Life Extension
                      LIFE EXTENSION The Life Extension Health News team delivers accurate information about vitamins, nutrition and aging. Our stories rely on multiple, authoritative sources and experts. We keep our content accurate and trustworthy, by submitting it to a medical reviewer. Life Extensionists are people who believe in taking advantage of documented scientific therapies to help maintain optimal health and slow aging. The medical literature contains thousands of references on the use of antioxidant vitamins, weight loss supplements, and hormones that have been shown to improve the quality and quantity of life. Life Extensionists attempt to take advantage of this scientific information to enhance their changes of living longer in good health. This article is posted by permission of Life Extension. https://www.lifeextension.com/

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                      This website is for informational and entertainment purposes only and is not a substitute for medical advice, diagnosis or treatment. FoodTrients – A Recipe for Aging Beautifully Grace O, author and creator of FoodTrients® -- a philosophy, a cookbook and a resource -- has a new cookbook dedicated to age-defying and delicious recipes, The Age Beautifully Cookbook: Easy and Exotic Longevity Secrets from Around the World, which provides one hundred-plus recipes that promote health and well-being. The recipes are built on foundations of modern scientific research and ancient knowledge of medicinal herbs and natural ingredients from around the world. Since the publication of her first anti-aging book, The Age GRACEfully Cookbook, Grace O has identified eight categories of FoodTrients benefits (Anti-inflammatory, Antioxidant, Immune Booster, Disease Prevention, Beauty, Strength, Mind, and Weight Loss) that are essential to fighting aging, which show how specific foods, herbs, and spices in the recipes help keep skin looking younger, prevent the diseases of aging, and increase energy and vitality. Grace O combines more exotic ingredients that add age-fighting benefits to familiar recipe favorites.

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