• It’s a Cookbook
    It’s a Philosophy
    It’s a Resource
logologologologo
  • FoodTrients 101 –
  • News –
      • Age Gracefully with Grace O
      • Ginger Hultin, Nutrition
      • Mark Rosenberg, MD
      • Robert Tostado, MD
      • Anti-Aging –
      • Beauty –
      • Food –
      • Health –
      • Exercise –
      • Celiac –
      • Life Extension
      • Books We Love –
      • FoodTrients Guides –
      • Newsletter –
      • capsule full of good foodAre Supplements Safe for You?
      • woman doing yogaSecrets of the Lymphatic System
      • woman fanning herselfWomen, Food, and Hormones: A Plan
      • "collagen" written on a chalkboardSave Your Eyes with Collagen
  • Recipes –
    • SEARCH BY:

      • Category:

      • Starters –
      • Soups –
      • Salads –
      • Main Dishes –
      • Sides –
      • Desserts –
      • Drinks –
      • Extras –
      • Spice Mixes –
      • All Recipes –
      • Or Search By:

      • Anti-inflammatory –
      • Antioxidant –
      • Beauty –
      • Detox –
      • Disease Prevention –
      • Gut Health –
      • Immunity Booster –
      • Mind –
      • Strength –
      • buffalo meat slidersBuffalo Sliders with Cranberries
      • exotic fruit and granolaExotic Fruit Salad with Granola
      • chocolate mousseDark Chocolate Mousse
      • Green Tea NoodlesGreen Tea Noodles with Edamame
  • Resources –
  • About –
  • Shop –
  • Media –
  • Home Page
  • News
    • Age Gracefully
    • Anti-Aging
    • Beauty
    • Food
    • Ginger Hultin, MS RDN CSO
    • Health
    • Newsletter
  • Recipes
    • Starters
    • Soups
    • Salads
    • Main Dishes
    • Sides
    • Desserts
    • Drinks
    • Extras
    • Spice Mixes
  • Resources
    • Anti-Aging Resources
    • Health
    • Eating Well
    • Books We Love
  • About
    • About Grace O
    • Experts and Advisors
    • Contact Us
    • Facebook
    • Instagram
    • YouTube
    • Pinterest
  • Shop
  • Media
    • In the Media
    • Press Releases
    • Videos
            No results See all results
            ✕
                      No results See all results

                      Curcumin Could Help Fight Mesothelioma

                      Published by Life Extension

                      Malignant mesothelioma, a cancer of the lining of the lungs that is largely attributable to asbestos exposure, could face a worthy opponent in the form of curcumin, a compound that occurs in the spice turmeric, according to research reported in October 2014 issue of Clinical Cancer Research.

                      Ashfin Dowlati and colleagues at University Hospitals Case Medical Center in Cleveland measured mesothelioma tumor expression of PIAS3 (protein inhibitor of activated STAT3), which is correlated with overall survival. They additionally evaluated the effects of PIAS3 activity on the intracellular protein and transcription factor STAT3 (signal transducer and activator of transcription 3), which can trigger cancer onset and growth. “In those mesothelioma patients where PIAS3 is low, indeed STAT3 is activated,” reported Dr Dowlati. “Mesothelioma patients who have low PIAS3 and high STAT3 have a greater chance of dying early. On the flip side, those patients with a high PIAS3 levels have a 44 percent decreased chance of dying in one year, which is substantial.”
                      The team found that STAT3 down regulation, via enhanced expression of PIAS3 or exposure to a peptide derived from PIAS3, inhibited cell growth and increased apoptosis. Administration of curcumin resulted in PIAS3 induction, indicating a potential role for the compound in mesothelioma therapy.

                      “Our findings suggest that PIAS3 expression positively affects survival in mesothelioma patients and that PIAS3 activation could become a therapeutic strategy,” Dr Dowlati commented. “Our interest for the future is that we want to find better, more simple ways to increase intracellular levels of PIAS3 for malignant mesothelioma through the use of synthetic PIAS3 peptide or curcumin analogs.”

                      “Our findings beg the question of what role PIAS3 could play in limiting STAT3 activation in other cancers as well,” he added. “There is an opportunity to extend this discovery because a number of cancers are STAT3-activated.”

                      Share
                      Life Extension
                      Life Extension
                      LIFE EXTENSION The Life Extension Health News team delivers accurate information about vitamins, nutrition and aging. Our stories rely on multiple, authoritative sources and experts. We keep our content accurate and trustworthy, by submitting it to a medical reviewer. Life Extensionists are people who believe in taking advantage of documented scientific therapies to help maintain optimal health and slow aging. The medical literature contains thousands of references on the use of antioxidant vitamins, weight loss supplements, and hormones that have been shown to improve the quality and quantity of life. Life Extensionists attempt to take advantage of this scientific information to enhance their changes of living longer in good health. This article is posted by permission of Life Extension.

                      Sign Up to get our
                      NEWSLETTER FREE

                      Select list(s) to subscribe to


                      By submitting this form, you are consenting to receive marketing emails from: FoodTrients, 14011 Ventura Blvd., Sherman Oaks, CA, 91423, http://www.foodtrients.com. You can revoke your consent to receive emails at any time by using the SafeUnsubscribe® link, found at the bottom of every email. Emails are serviced by Constant Contact

                      Latest Articles

                      • 0
                        Shrimp and Grapefruit Salad
                        January 27, 2023
                      • 0
                        Feeling Down? It May Not Be Just The Winter Blues…
                        January 25, 2023
                      • 0
                        Centenarians Abound in Isolated Nicoya
                        January 19, 2023
                      • It’s Citrus Season and the Squeeze Is On!
                        January 18, 2023
                      • 0
                        Discover the Many-Splendored Foods of Malta
                        January 15, 2023

                      SEE MORE

                      ABOUT

                      • Grace O
                      • Our Experts
                      • FoodTrients
                      • Board of Advisors
                      • FAQs

                      EXPLORE

                      • Age Gracefully by Grace O
                      • News
                      • Recipes
                      • Our Guides
                      • Resources
                      • Shop
                      • Media

                      CONNECT

                      • Contact Us
                      • Subscribe
                      • Facebook
                      • Pinterest
                      • Instagram
                      • Twitter
                      • YouTube

                      SIGN UP for our NEWSLETTER

                      Nourish your week! Get the latest wellness news and delicious recipes to help you age better.

                      Select list(s) to subscribe to


                      By submitting this form, you are consenting to receive marketing emails from: FoodTrients, 14011 Ventura Blvd., Sherman Oaks, CA, 91423, http://www.foodtrients.com. You can revoke your consent to receive emails at any time by using the SafeUnsubscribe® link, found at the bottom of every email. Emails are serviced by Constant Contact

                      FoodTrients Trademark™ and copyright © 2011-2022 Triple G Enterprises. I Terms and Conditions I Privacy

                      This website is for informational and entertainment purposes only and is not a substitute for medical advice, diagnosis or treatment. FoodTrients – A Recipe for Aging Beautifully Grace O, author and creator of FoodTrients® -- a philosophy, a cookbook and a resource -- has a new cookbook dedicated to age-defying and delicious recipes, The Age Beautifully Cookbook: Easy and Exotic Longevity Secrets from Around the World, which provides one hundred-plus recipes that promote health and well-being. The recipes are built on foundations of modern scientific research and ancient knowledge of medicinal herbs and natural ingredients from around the world. Since the publication of her first anti-aging book, The Age GRACEfully Cookbook, Grace O has identified eight categories of FoodTrients benefits (Anti-inflammatory, Antioxidant, Immune Booster, Disease Prevention, Beauty, Strength, Mind, and Weight Loss) that are essential to fighting aging, which show how specific foods, herbs, and spices in the recipes help keep skin looking younger, prevent the diseases of aging, and increase energy and vitality. Grace O combines more exotic ingredients that add age-fighting benefits to familiar recipe favorites.

                                No results See all results