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                      Quercetin: Good As Resveratrol In Fighting Inflammation

                      Published by Life Extension

                      Research described online in the American Journal of Clinical Nutrition revealed that the ability of quercetin to reduce inflammation and insulin resistance in human fat cells is equal to or greater than that of resveratrol, a well-known plant compound that has an anti-inflammatory benefit. Quercetin is a flavonol found in plants including apples, onions, capers, lovage and grapes which have known antioxidant and anti-inflammatory properties.

                      Michael K. McIntosh and his colleagues at the University of North Carolina in Greensboro pretreated cultured human adipocytes (fat cells) with quercetin or trans-resveratrol, followed by tumor necrosis factor-alpha (TNF-a), a proinflammatory cytokine that contributes to chronic, low grade inflammation, which occurs in obesity.

                      Quercetin and resveratrol were rapidly taken up by the adipocytes. Both compounds lowered TNF-a induced expression of inflammatory genes, including interleukin 6, interleukin 8 and monocyte chemoattractant protein-1, as well as the secretion of these proinflammatory compounds. The effect of quercetin was greater than that of resveratrol. Quercetin was also found to have a greater impact on other factors, including the ability to reduce nuclear factor-kappa B transcription and insulin resistance induced by TNF-a.

                      “To our knowledge, this is the first study to show that quercetin and trans-resveratrol aglycones are taken up by primary human adipocytes,” the authors write. “Notably, consuming whole foods or supplements rich in phytochemicals such as quercetin and resveratrol provide many important health benefits. These benefits are most likely due to their ability to attenuate oxidative stress and inflammation, as shown in the current study and in other in vitro studies.”

                      “These data suggest that quercetin is equally or more effective than trans-resveratrol in attenuating TNF-a–mediated inflammation and insulin resistance in primary human adipocytes,” they conclude.

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                      Life Extension
                      Life Extension
                      LIFE EXTENSION The Life Extension Health News team delivers accurate information about vitamins, nutrition and aging. Our stories rely on multiple, authoritative sources and experts. We keep our content accurate and trustworthy, by submitting it to a medical reviewer. Life Extensionists are people who believe in taking advantage of documented scientific therapies to help maintain optimal health and slow aging. The medical literature contains thousands of references on the use of antioxidant vitamins, weight loss supplements, and hormones that have been shown to improve the quality and quantity of life. Life Extensionists attempt to take advantage of this scientific information to enhance their changes of living longer in good health. This article is posted by permission of Life Extension. https://www.lifeextension.com/

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                      This website is for informational and entertainment purposes only and is not a substitute for medical advice, diagnosis or treatment. FoodTrients – A Recipe for Aging Beautifully Grace O, author and creator of FoodTrients® -- a philosophy, a cookbook and a resource -- has a new cookbook dedicated to age-defying and delicious recipes, The Age Beautifully Cookbook: Easy and Exotic Longevity Secrets from Around the World, which provides one hundred-plus recipes that promote health and well-being. The recipes are built on foundations of modern scientific research and ancient knowledge of medicinal herbs and natural ingredients from around the world. Since the publication of her first anti-aging book, The Age GRACEfully Cookbook, Grace O has identified eight categories of FoodTrients benefits (Anti-inflammatory, Antioxidant, Immune Booster, Disease Prevention, Beauty, Strength, Mind, and Weight Loss) that are essential to fighting aging, which show how specific foods, herbs, and spices in the recipes help keep skin looking younger, prevent the diseases of aging, and increase energy and vitality. Grace O combines more exotic ingredients that add age-fighting benefits to familiar recipe favorites.

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