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                      Broccoli Compound May Help Maintain Colon

                      Published by Life Extension

                      Fresh Washed Broccoli

                      An article appearing on August 14, 2018 in the journal Immunity suggests a role for broccoli and other vegetables belonging to the Brassica genus in helping to maintain intestinal health and prevent colon cancer.

                      When these vegetables are consumed, a compound known as indole-3-carbinol (I3C) is formed, which activates the aryl hydrocarbon receptor (AhR) protein that carries signals to immune cells and epithelial cells. Researchers Amina Metidji of the Francis Crick Institute and colleagues determined that this protein is important for repairing damage to the epithelial cells that line the intestinal tract.

                      “We studied genetically modified mice that cannot produce or activate AhR in their guts and found that they readily developed gut inflammation which progressed to colon cancer,” Dr Metidji explained. “However, when we fed them a diet enriched with I3C, they did not develop inflammation or cancer. Interestingly, when mice whose cancer was already developing were switched to the I3C-enriched diet, they ended up with significantly fewer tumors which were also more benign.”

                      “Seeing the profound effect of diet on gut inflammation and colon cancer was very striking,” commented senior author Gitta Stockinger. “We often think of colon cancer as a disease promoted by a Western diet rich in fat and poor in vegetable content, and our results suggest a mechanism behind this observation. Many vegetables produce chemicals that keep AhR stimulated in the gut. We found that AhR-promoting chemicals in the diet can correct defects caused by insufficient AhR stimulation. This can restore epithelial cell differentiation, offering resistance to intestinal infections and preventing colon cancer.”

                      “Now that we’ve demonstrated the mechanistic basis for this in mice, we’re going to investigate these effects in human cells and people,” Dr Gitta added. “In the meantime, there’s certainly no harm in eating more vegetables!”

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                      Life Extension
                      Life Extension
                      LIFE EXTENSION The Life Extension Health News team delivers accurate information about vitamins, nutrition and aging. Our stories rely on multiple, authoritative sources and experts. We keep our content accurate and trustworthy, by submitting it to a medical reviewer. Life Extensionists are people who believe in taking advantage of documented scientific therapies to help maintain optimal health and slow aging. The medical literature contains thousands of references on the use of antioxidant vitamins, weight loss supplements, and hormones that have been shown to improve the quality and quantity of life. Life Extensionists attempt to take advantage of this scientific information to enhance their changes of living longer in good health. This article is posted by permission of Life Extension.

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                      This website is for informational and entertainment purposes only and is not a substitute for medical advice, diagnosis or treatment. FoodTrients – A Recipe for Aging Beautifully Grace O, author and creator of FoodTrients® -- a philosophy, a cookbook and a resource -- has a new cookbook dedicated to age-defying and delicious recipes, The Age Beautifully Cookbook: Easy and Exotic Longevity Secrets from Around the World, which provides one hundred-plus recipes that promote health and well-being. The recipes are built on foundations of modern scientific research and ancient knowledge of medicinal herbs and natural ingredients from around the world. Since the publication of her first anti-aging book, The Age GRACEfully Cookbook, Grace O has identified eight categories of FoodTrients benefits (Anti-inflammatory, Antioxidant, Immune Booster, Disease Prevention, Beauty, Strength, Mind, and Weight Loss) that are essential to fighting aging, which show how specific foods, herbs, and spices in the recipes help keep skin looking younger, prevent the diseases of aging, and increase energy and vitality. Grace O combines more exotic ingredients that add age-fighting benefits to familiar recipe favorites.

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