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                      Vitamin C Shows Promise As Brain Aging Treatment

                      Published by Life Extension

                      Vitamin C structure

                      A study reported on January 9, 2019 in the journal Nutrients revealed a protective role for supplementation with vitamin C, a well known antioxidant, in mice exposed to D-galactose, a sugar that occurs in some foods which has been shown to induce brain aging via the accumulation of oxidative stress.

                      One hundred-eight mice were divided to receive subcutaneous D-galactose or no D-galactose for 10 weeks. Beginning in the seventh week, half of the animals in each group were given a high oral dose of vitamin C for four weeks.

                      While mice that received D-galactose experienced a reduction in cognitive function and decreased neurogenesis in the brain’s hippocampus (an area associated with memory), animals that received vitamin C showed no reduction in hippocampal neurogenesis, which was attributed to improvements in cellular proliferation, neuronal differentiation and neuronal maturation. Furthermore, vitamin C was associated with protection against the upregulation of inflammatory factors and downregulation of the antioxidants superoxide dismutase (SOD) 1 and 2, sirtuin 1 and other factors in the hippocampus. Animals that received vitamin C additionally showed enhanced hippocampus-dependent memory function.

                      According to authors Sung Min Nam of Korea’s Konkuk University and colleagues, the decline in the production of the antioxidant enzymes SOD1 and SOD2 could be responsible for the increase in oxidative stress associated with D-galactose.

                      “Ascorbic acid-mediated beneficial effects on brain aging may be achieved by several mechanisms, including the promotion of neurogenesis and synaptic plasticity; increase in endogenous antioxidants; attenuation of neuroinflammation; and enhanced expression of Sirt1, caveolin-1, and brain-derived neurotrophic factor, in the hippocampus impaired by D-galactose,” they write. “These mechanisms might account for the subsequent functional improvement in hippocampus-dependent memory. Therefore, our findings suggest that ascorbic acid is a useful anti-brain aging agent.”

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                      Life Extension
                      Life Extension
                      Life Extensionists are people who believe in taking advantage of documented scientific therapies to help maintain optimal health and slow aging. The medical literature contains thousands of references on the use of antioxidant vitamins, weight loss supplements, and hormones that have been shown to improve the quality and quantity of life. Life Extensionists attempt to take advantage of this scientific information to enhance their chances of living longer in good health.

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                      This website is for informational and entertainment purposes only and is not a substitute for medical advice, diagnosis or treatment. FoodTrients – A Recipe for Aging Beautifully Grace O, author and creator of FoodTrients® -- a philosophy, a cookbook and a resource -- has a new cookbook dedicated to age-defying and delicious recipes, The Age Beautifully Cookbook: Easy and Exotic Longevity Secrets from Around the World, which provides one hundred-plus recipes that promote health and well-being. The recipes are built on foundations of modern scientific research and ancient knowledge of medicinal herbs and natural ingredients from around the world. Since the publication of her first anti-aging book, The Age GRACEfully Cookbook, Grace O has identified eight categories of FoodTrients benefits (Anti-inflammatory, Antioxidant, Immune Booster, Disease Prevention, Beauty, Strength, Mind, and Weight Loss) that are essential to fighting aging, which show how specific foods, herbs, and spices in the recipes help keep skin looking younger, prevent the diseases of aging, and increase energy and vitality. Grace O combines more exotic ingredients that add age-fighting benefits to familiar recipe favorites.

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