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                      Revealing The Mystery of Aging

                      Published by Life Extension

                      Researchers have long puzzled by the mystery of aging in humans and great efforts have been put in to the attempt of discovery of the missing link. Now a National Cheng Kung University (NCKU) transnational research team has made a new discovery of aging mechanisms.

                      Dr. Jung-Hsien Chiang from the Department of Computer Science and Information Engineering, who leads the NCKU team, has revealed that the mechanisms of aging is associated with the nuclear pore complexes (NPCs) as an active participant in gene silencing and the formation of peripheral heterochromatin.

                      The groundbreaking study carried out by Taiwan’s NCKU together with Canada’s University of Alberta (UAlberta) and US’s Institute for Systems Biology (ISB) has published in the February 28, 2013 issue of CELL.

                      The paper titled “A Role for the Nucleoporin Nup170p in Chromatin Structure and Gene Silencing” describes the revolutionary findings in which the seven-member transnational research team draws a clear picture that the role of yeast NPC protein Nup170p in subtelomeric gene silencing is linked to its association with the chromatin-remodeling complex.

                      Chiang explained that the aging of cells is closely related to telomere length and each time a cell divides, the telomere gets shorter and eventually leads to cell death; however, to date, it is unclear what functional role NPCs play in establishing and maintaining distinct chromatin domains within living cells.

                      “Our team has uncovered that the binding of Nup170p to subtelomeric chromatin is cooperative and necessary for the association of telomeres with the nuclear envelope, which is a comprehensive roadmap to explain that Nup170p plays a physiological role at telomeres,” Chiang added.

                      The team also successfully illustrates that the Nup170p with regions of the genome that contain ribosomal protein and subtelomeric genes, where it functions in as a repressor of transcription.

                      Chiang said, “This is the first time that we unveil functional interactions between Nup170p and chromatin domains that generally reside adjacent to the nuclear envelope, including subtelomeric and telomeric regions.”

                      The members of the team are eminent scholars in their own fields in which UAlberta taking charge of cell biology; ISB responsible for gene expression profiling; NCKU focusing on bioinformatics computing.

                      Chiang’s team in NCKU tackles with the data retrieving from the research and systematical computation provided by NCKU has facilitated deciphering the mystery of aging.

                      Copyright Business Wire 2013

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                      Life Extension
                      Life Extension
                      LIFE EXTENSION The Life Extension Health News team delivers accurate information about vitamins, nutrition and aging. Our stories rely on multiple, authoritative sources and experts. We keep our content accurate and trustworthy, by submitting it to a medical reviewer. Life Extensionists are people who believe in taking advantage of documented scientific therapies to help maintain optimal health and slow aging. The medical literature contains thousands of references on the use of antioxidant vitamins, weight loss supplements, and hormones that have been shown to improve the quality and quantity of life. Life Extensionists attempt to take advantage of this scientific information to enhance their changes of living longer in good health. This article is posted by permission of Life Extension.

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                      This website is for informational and entertainment purposes only and is not a substitute for medical advice, diagnosis or treatment. FoodTrients – A Recipe for Aging Beautifully Grace O, author and creator of FoodTrients® -- a philosophy, a cookbook and a resource -- has a new cookbook dedicated to age-defying and delicious recipes, The Age Beautifully Cookbook: Easy and Exotic Longevity Secrets from Around the World, which provides one hundred-plus recipes that promote health and well-being. The recipes are built on foundations of modern scientific research and ancient knowledge of medicinal herbs and natural ingredients from around the world. Since the publication of her first anti-aging book, The Age GRACEfully Cookbook, Grace O has identified eight categories of FoodTrients benefits (Anti-inflammatory, Antioxidant, Immune Booster, Disease Prevention, Beauty, Strength, Mind, and Weight Loss) that are essential to fighting aging, which show how specific foods, herbs, and spices in the recipes help keep skin looking younger, prevent the diseases of aging, and increase energy and vitality. Grace O combines more exotic ingredients that add age-fighting benefits to familiar recipe favorites.

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