Onion Compound Suppresses Cancer Cells

Golden onions on rustic wooden background

This pungent vegetable has previously been cited for its health benefits, including lowering risk of certain cancers and helping with depression. But now, a new study has found that a compound found in onions has anti-ovarian cancer effects.

After examining the effects of ONA on a preclinical model of EOC in cells, the researchers found that the growth of EOCs slowed down after the team introduced ONA.

They also discovered that ONA inhibited pro-tumor activities of myeloid-derived suppressor cells (MDSC), which the researchers say are linked with the suppression of the anti-tumor immune response of host lymphocytes.

Furthermore, they found that ONA enhanced anti-cancer drugs’ effects by boosting their anti-proliferation ability.

In further experiments on an ovarian cancer mouse model, the researchers used oral doses of ONA. Results showed that the mice had longer lifespans and showed diminished ovarian cancer tumor development.

The researchers say their study demonstrates that ONA slows progression of ovarian cancer tumors by interrupting myeloid cells’ pro-tumor activity.

They add: “We found that ONA reduced the extent of ovarian cancer cell proliferation induced by co-culture with human macrophages. In addition, we found that ONA directly suppressed cancer cell proliferation.

Thus, ONA is considered useful for the additional treatment of patients with ovarian cancer owing to its suppression of the pro-tumor activation of [tumor-associated macrophages] and direct cytotoxicity against cancer cells.”

The investigators did not observe side effects in animals, and they say with more testing, an oral ONA supplement could help cancer patients.

They conclude their study by noting it is the first to report an anti-ovarian cancer effect of ONA.

In a previous study, the same research team found that ONA suppressed the pro-tumor activation of host myeloid cells.

About Life Extension

Life Extensionists are people who believe in taking advantage of documented scientific therapies to help maintain optimal health and slow aging. The medical literature contains thousands of references on the use of antioxidant vitamins, weight loss supplements, and hormones that have been shown to improve the quality and quantity of life. Life Extensionists attempt to take advantage of this scientific information to enhance their chances of living longer in good health.
What Do FoodTrients Do?
Ai Anti- inflammatories

Reduce inflammatory process in cells, tissues, and blood vessels, helping to slow aging and reduce risk of long-term disease.

Ao Anti- oxidant

Prevents and repairs oxidative damage to cells caused by free radicals.

IB Immunity Boosters

Support the body’s resistance to infection and strengthen immune vigilance and response.

MB Mind

Improves mood, memory, and focus.

F Disease Prevention

Reduces risk factors for common degenerative and age-related diseases.